Protective Effect of Isoliquiritigenin against Ethanol-Induced Hepatic Steatosis by Regulating the SIRT1-AMPK Pathway

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Protective Effect of Isoliquiritigenin against Ethanol-Induced Hepatic Steatosis by Regulating the SIRT1-AMPK Pathway

Ethanol-induced fat accumulation, the earliest and most common response of the liver to ethanol exposure, may be involved in the pathogenesis of liver diseases. Isoliquiritigenin (ISL), an important constituent of Glycyrrhizae Radix, is a chalcone derivative that exhibits antioxidant, anti-inflammatory, and phytoestrogenic activities. However, the effect of ISL treatment on lipid accumulation i...

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Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/Sirt1 activation

BACKGROUND Alcoholic steatosis is the earliest and most common liver disease, and may precede the onset of more severe forms of liver injury. METHODS The effect of Korean Red Ginseng extract (RGE) was tested in two murine models of ethanol (EtOH)-feeding and EtOH-treated hepatocytes. RESULTS Blood biochemistry analysis demonstrated that RGE treatment improved liver function. Histopathology ...

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ژورنال

عنوان ژورنال: Toxicological Research

سال: 2018

ISSN: 1976-8257,2234-2753

DOI: 10.5487/tr.2018.34.1.023